Ingredient By Ingredient

The Ingredients

Straight Up

Vitamin D, B6 (P5P), Pantothenic Acid, Zinc, Ashwagandha, Black Cumin, Soy Isoflavones, Black Cohosh, Chasteberry, and Rheum Rhaponticum.

Every ingredient and dose is named on the label — no proprietary blend.

Graded by evidence, not marketing

Each ingredient below is labeled by how well the published clinical research actually supports its role — not by how confidently the sales copy states it.

Vitamin D — 40mcg (200% DV)

Supports bone mineral density, which becomes more important as estrogen decline accelerates bone resorption. Within commonly studied supplemental ranges.

Vitamin B6 (P5P form) — 20mg (1,176% DV)

The active, immediately bioavailable form — a quality choice over cheaper pyridoxine HCl. Central to serotonin and dopamine synthesis, relevant to mood instability during the transition.

Pantothenic Acid — 100mg (2,000% DV)

Essential for coenzyme A synthesis, central to energy metabolism and adrenal hormone production, which becomes more relevant as ovarian estrogen production declines.

Zinc — 15mg (136% DV)

An essential trace mineral involved in hormone-metabolism enzyme regulation. Sits well within the NIH's tolerable upper limit.

Ashwagandha Root — 300mg STRONG EVIDENCE

One of the stronger evidence bases in this category. A 2019 RCT found reduced perceived stress and cortisol; a 2021 RCT in menopausal women specifically found improvements in hot-flash frequency and sleep. Can interact with thyroid medications, immunosuppressants, and sedatives.

Black Cumin Seed — 250mg, 5% Thymoquinone MIXED EVIDENCE

Antioxidant and anti-inflammatory research, standardized to a defined potency — a meaningful quality signal, though not menopause-specific research.

Soy Isoflavones — 40mg STRONG EVIDENCE

Fair to mention: a 2021 meta-analysis found modest but statistically significant reductions in hot-flash frequency. Effect depends partly on "equol-producer" status — only 30-50% of Western populations convert isoflavones to this more bioactive metabolite. Contains soy; not appropriate for those with a soy allergy or hormone-sensitive condition history without oncologist clearance.

Black Cohosh Root — 40mg MIXED EVIDENCE

One of the most studied menopause botanicals, with genuinely mixed trial results — some large RCTs show no benefit, others show improvement for hot flashes specifically. Not recommended during pregnancy; liver-condition caution advised.

Chasteberry — 40mg MIXED EVIDENCE

A long history in European herbal medicine for cycle-related support, particularly relevant in perimenopause. More traditional-use evidence than deep clinical trial data.

Rheum Rhaponticum — 4mg STRONG EVIDENCE

The least familiar ingredient but arguably the most targeted: this dose aligns with the ERr 731 clinical research line, evaluated in multiple RCTs for hot flashes, sleep, and mood. That research was on a specific standardized extract, so it doesn't automatically transfer to this exact product.